Seminar: DNA Hybridization on Surfaces

Khwarzimic Science Society brings you....

Seminar:

DNA Hybridization on Surfaces

Speaker: Fouzia Bano, SISSA International School of Advanced
Studies, Trieste, Italy.

Venue: Center for Solid State Physics, University of the Punjab,
Lahore.

Time and Date: 7/28/2008 (month/day/year)

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Introduction:

The controlled arrangement of DNA molecules on surfaces represents
one challenging contribution of nanotechnology to biology and
medicine. In particular, one of the open issues in the field of DNA-
based sensors is detecting the hybridization process with high
precision in a real-life biological environment. Towards this end, we
have studied the hybridization of single stranded (ss)-DNA anchored
on a gold surface using the increase in height of the molecules upon
hybridization with a label free target which is due to the much
larger rigidity of ds- vs. ss-DNA. Nano-scale ss-DNA patches are
assembled within oligo-ethylene- glycol terminated alkylthiol self-
assembled monolayer on a gold substrate using nanografting (an atomic
force microscopy-based nanolithography technique). Differential
height measurements indicate that ss-DNA nano-patches do not show
significant increase in height upon hybridization with complementary
strands in high density regime. Moreover, the advantage of this
system for biosensors and genomics applications will be discussed
briefly in the end.



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[Article of the Month] Science and the Islamic World

Dr. Pervez Hoodbhoy has been a faculty member at the Quaid-e-Azam University since 1973. In 1984 he received the Abdus Salam Prize for mathematics and is the author of 65 scientific research papers.

He recently authored an article published in the Physics Today monthly, Science and the Islamic World - A Quest for rapprochement. Here Dr Hoodbhoy discusses the past, present and prospective future for the development of Scientific thought in the Muslim World.

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