Seminar: DNA Hybridization on Surfaces

Khwarzimic Science Society brings you....

Seminar:

DNA Hybridization on Surfaces

Speaker: Fouzia Bano, SISSA International School of Advanced
Studies, Trieste, Italy.

Venue: Center for Solid State Physics, University of the Punjab,
Lahore.

Time and Date: 7/28/2008 (month/day/year)

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Introduction:

The controlled arrangement of DNA molecules on surfaces represents
one challenging contribution of nanotechnology to biology and
medicine. In particular, one of the open issues in the field of DNA-
based sensors is detecting the hybridization process with high
precision in a real-life biological environment. Towards this end, we
have studied the hybridization of single stranded (ss)-DNA anchored
on a gold surface using the increase in height of the molecules upon
hybridization with a label free target which is due to the much
larger rigidity of ds- vs. ss-DNA. Nano-scale ss-DNA patches are
assembled within oligo-ethylene- glycol terminated alkylthiol self-
assembled monolayer on a gold substrate using nanografting (an atomic
force microscopy-based nanolithography technique). Differential
height measurements indicate that ss-DNA nano-patches do not show
significant increase in height upon hybridization with complementary
strands in high density regime. Moreover, the advantage of this
system for biosensors and genomics applications will be discussed
briefly in the end.



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Magnetic Resonance - Lecture @ KSS, Lahore | May 9th

Speaker: Dr. Sabieh Anwar, Assistant Professor, Physics,
School of Science and Engineering, LUMS

Day and date: Wednesday, 9 May, 2007

Time: 11 am

Venue: Institute of Biochemistry and Biotechnology, Punjab
University, Quaid-e-Azam Campus, Lahore 54590

Abstract:

Nuclear magnetic resonance (NMR) is a technique that exploits the spin of certain nuclei to obtain a tell-tale signatures of the molecules. This technique finds immense use in diagnostic imaging of human tissue. We will explore the origins of the NMR effect. In addition to its medical uses, we will also address other novel and esoteric applications, such as quantum computing, low-field NMR, explosives detection, polymer and foodstuff characterization, single-cell and
nano particle MRI.

For information contact: info@khwarzimic.org

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